Hydrogels with well-defined peptide-hydrogel spacing and concentration: impact on epithelial cell behavior

Epithelial contact guidance on well-defined micro- and nanostructured substrates.

The human corneal basement membrane has a rich felt-like surface topography with feature dimensions between 20 nm and 200 nm. On the basis of these findings, we designed lithographically defined substrates to investigate whether nanotopography is a relevant stimulus for human corneal epithelial cells. We found that cells elongated and aligned along patterns of grooves and ridges with feature di...

Synthesis of well-defined hydrogel networks using click chemistry.

New PEG-based hydrogel materials have been synthesized by Click chemistry and shown to result in well-defined networks having significantly improved mechanical properties; the selectivity of the azide/acetylene coupling reaction also allows for the incorporation of various additives and functional groups leading to chemical tailoring of the hydrogels.

Mitochondrial Haplogroups and Well Defined Populations

Electrochemical Hydrogel Lithography of Calcium-Alginate Hydrogels for Cell Culture

Here we propose a novel electrochemical lithography methodology for fabricating calcium-alginate hydrogels having controlled shapes. We separated the chambers for Ca2+ production and gel formation with alginate with a semipermeable membrane. Ca2+ formed in the production chamber permeated through the membrane to fabricate a gel structure on the membrane in the gel formation chamber. When the ca...

Impact of Religious Coping Techniques on the Well-being and Behavior Regulation of Adolescent Girls Struggling with Behavioral Issues

Context and Objectives: Adolescence stands out as a critical phase marked by intricate psychological and physiological shifts, often leading to unstable mental states and subsequent behavioral challenges. This study aimed to explore the impact of instruction in religious coping strategies on the overall well-being and regulation of behavioral inhibition and activation systems among adolescent g...